Research at LETGEN

Our work has focused on the contributions of heavy metals collected from road-side and dust collections collected from various locations on the islands. We are using gene expression profiling of lung cells to model exposures to investigate effects of volcanic emissions on regulation of cell proliferation and other processes related to respiratory disease.

Below is a Comet assay image and bar chart (mean + SD) of the rat

DNA damage in L2 cells induced by exposure to ozone

lung cell line L2 (ATCC CCL-149) one hour, four hours, or twenty-four hours after exposure to Air or Ozone (0.2 ppm) for 30 minutes. DNA damage is a well recognized consequence of exposure to ozone. Note that by 24 hours back to control levels.